 History of Laboratory of
Experimental radiation oncology in this department is directed toward developing a
greater understanding of the molecular and genetic basis of response of mammalian cells
and tissues to fractionated schedules of ionizing radiation, hyperthermia and/or
chemotherapy (including antisense oligonucleotides or antipeptides). The goal remains the
enhancement of the therapeutic ratio by novel approaches to translational research. The
direction of active research toward this goal includes elucidation of basic mechanisms
leading to therapeutic strategies for modification of radiation response. These strategies
include modulation of check points and altered cell cycle progression, establishment of an
in vitro DNA repair system for modification of DNA repair processes and DNA damage
expression, radiation sensitization and hyperthermia (thermoradiotherapy).
Predictive assays are also being developed. The
experimental environment includes both the laboratory and the clinic with
attention equally to acute and late effects. |
The Laboratory of Experimental Radiation
Oncology is one of the more active radiation biology groups in the country.
Research activities in the Laboratory of Experimental Oncology are currently
funded by approximately $2.0 million annually in research grants from the
National Cancer in addition to departmental and industrial support.
There are seven full time
faculty members and one adjunct faculty member. The Laboratory
consists of approximately 13,000 ft2 located in three sections. The
main laboratory complex is in the basement of Main and Thompson Buildings,
and a suite of laboratories is located in the Bodine Center for Cancer
Treatment and the Bluemle Life Sciences Building. The faculty include:
Adam P. Dicker, M.D., Ph.D., Division Director
Dennis B. Leeper, Ph.D.
Ronald A. Coss, Ph.D.
Ya Wang, M.D., Ph.D.
Phyllis R. Wachsberger, Ph.D.
Kulbir Sidhu, M.D.
Randy M. Burd, Ph.D.
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