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3D-CRT + Implant Boost

Clinical staging of prostate cancer.

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For adenocarcinoma of the prostate local control of tumor is directly related to radiation dose. The challenge has been for physicians to increase the tumor dose while at the same time minimizing the volume of normal tissue within the high-dose volume. One avenue is the use of three-dimensional conformal radiotherapy, utilizing CT imaging to shape and design radiation fields that conform more closely to the shape of the prostate. By use of more tailored radiation beams the radiation dose can be increased without increasing the complication rate(s). Another avenue of dose escalation is a brachytherapy boost. To date, for patients with more advanced disease (Gleason score greater than 7, or PSA greater than 10 ng/ml, or Stage T3 disease) external beam radiation therapy in combination with a brachytherapy boost has offered some of the highest cure rates to date. This is an area of active investigation at Thomas Jefferson University.

PSA as a staging tool: Partin's tables

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PSA as a staging tool: Partin's tables (continued)

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3D Conformal Radiation Therapy

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