Ruben Fragoso, M.D./Ph.D.
Resident, Department of Radiation Oncology, Thomas Jefferson University
Email:
Ruben.Fragoso@jeffersonhospital.org
Dr. Ruben Fragoso has served as a resident in the Department of Radiation Oncology
at Thomas Jefferson University Hospital since July 2005. Prior, he completed his medical internship year at Morristown
Memorial Hospital in Morristown, NJ. Dr. Fragoso received his MD/PhD degree from Harvard University in June 2004. His
doctoral thesis focused on the signaling requirements driving CD8 single positive thymocyte maturation. He received a
Bachelor of Arts in Molecular Biology from Princeton University in June 1992.
Publications:
Fragoso RC, Pyarajan S, Irie HY and Burakoff SJ. "Reconstitution of CD8 single positive
T cells using a chimeric CD8α-Lck transgene." J Immunol. 2006, 177: 6007-17.
Fragoso R, Ren D, Zhang X. Su M, Burakoff SJ and Jin Y-J. "Lipid raft distribution of CD4 depends
on its palmitoylation and association with Lck, and evidence for CD4-Induced lipid raft aggregation as an additional mechanism
to enhance CD3 signaling." J Immunol. 2003, 170: 913-921.
Fragoso RC, Su MW-C and Burakoff SJ. "T Cells and Their Effector Functions." Encyclopedia of Cancer,
Second Edition. 2002, Vol. 4:339-351.
Halamay KE, Kirkman RL, Sun L, Yamada A, Fragoso RC, Shimizu K, Mictchell RN, McKay DB. "CD8 T cells
are sufficient to mediate allorecognition and allograft rejection." Cellular Immunol. 2002, 216:6-14.
Sen J, Kapeller R, Fragoso R, Sen R, Zon LI and Burakoff SJ. "Intrathymic signals in thymocytes
are mediated by p38 mitogen-activated protein kinase." J Immunol. 1996, 156:4535-4538.
Chauhan D, Kharbanda S, Uchiyama H, Urashima M, Fragoso R, Sen J, Kufe DW and Anderson KC.
"Identification of upstream signals regulating interleukin-6 gene expression during in vitro treatment of human B cells
with pokeweed mitogen." Blood. 1994, 84:2243-2252.
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