Dr. London's medical informatics research efforts are focused on the application of computer technology to cancer-related basic science and cancer clinical trials research. To facilitate basic science research at KCC, Dr. London's work involves the development of intranet-based translational research data acquisition. The intranet is used to acquire research data from multiple laboratories and clinical departments associated with program projects. The goal is to facilitate data entry, while providing secure access to all the laboratories' data for comprehensive analysis and review, including biostatistical analysis.
Development also continues on a repository of available tissue specimens for biomarker research with researchers from other NCI-designated cancer center members of the Pennsylvania Cancer Alliance. This project utilizes web-based databases for the acquisition and display of available biospecimens.
Dr. London represents the KCC for the NCI's Cancer Biomedical Informatics Grid (caBIG) initiative, which is building a national grid connecting individuals and institutions to enable the sharing of data and tools, creating a World Wide Web of cancer research. KCC is a funded developer for the Integrated Cancer Research (ICR) workspace, and a funded adopter in the Pathology and Tumor Bank Tools (TBPT) workspace. The ICR workspace project involves the adoption and modification of the NCI Center for Bioinformatics' (NCICB) microarray data portal, caARRAY. Dr. London's group is modifying the portal so that it can be integrated into the workflow normally found in cancer centers. The TBPT workspace project centers on the adoption of the caTISSUE CORE software application for biospecimen banking, and its integration into the informatics infrastructure at KCC. KCC is also a funded adopter in another TBPT project, the cancer Text Information Extraction System (caTIES). This project involves the automatic extraction of text from surgical pathology reports and the de-identification of the information for HIPAA compliance. When completed, caTIES will provide automated annotation for tissue bank databases with information found in surgical pathology reports. Dr. London also is a funded participant in the caBIG Data Sharing and Intellectual Capital work group, which is setting policy for the complex data sharing and intellectual capital issues involved in the establishment of a national research grid.
Dr. London's involvement in clinical research encompasses the development of computer systems for clinical trials, IRB, and Data Safety Monitoring (human subjects protection). An application to automate the calculations involved in patient chemotherapy regimens was developed by Dr. London's group, and is deployed at Thomas Jefferson University Hospital.
Keywords: bioinformatics, medical informatics
Li F., Smalley K., and London J.W.: Adapting caArray to a Cancer Center’s Workflow, NCI caBIG Annual Meeting, Washington, DC. April 2005.
London J.W. , Mervis S., and Kalf, G.F.: Tools for thePerformance of Clinical Trials Research, 11th World Congress on MedicalInformatics, San Francisco 2004.
R. Brandell-Marino, A. M. Valorie, C. Senholzi, J. London, and J.Filicko, Web Based Chemotherapy Ordering, American Society ofHealth-System Pharmacists 38th Midyear Clinical Meeting, New Orleams,2003.
London J.W. and Mervis S.: Cancer Clinical Trials Treatment Management Application, 10th World Congress on Health and Medical Informatics, London 2001.
Monzon F., London, J. W., and Palazzo J. P. Development of Web-Based Support Tools for a Comprehensive Breast Cancer Tissue and Data Procurement Program. (abstract) Modern Pathology 14:1, 234A (2001).
London JW, Gomella LG. Overview of the Internet and prostate cancer resources. Semin Urol Oncol 2000 Aug;18(3):245-53.. ( Abstract )
London J.W.: oncology on the Internet, National Medical Association Annual Meeting, Washington, DC, 2000.
London J. W.: Lay Public Use of Healthcare Web Sites. In The Handbook of Healthcare Information Systems, P. L. Davidson, ed., CRC Press, Boca Raton, 2000, pp. 495-506.
London J.W.: Web-based protocol patient treatment scheduling, National Cancer Institute Technology Expo, American Medical Informatics Association Annual Symposium, Washington, DC, 1999.
London J.W.: oncology on the Internet, National Medical Association Annual Meeting, Las Vegas, 1999.
London J.W.: Intranet Databases for Clinical Trials and Translational Research, Cancer Center Administrators’ Forum, Nashville, 1998.
London JW, Morton DE, Marinucci D, Catalano R, Comis RL. The implementation of telemedicine within a community cancer network. J Am Med Inform Assoc 1997 Jan-Feb;4(1):18-24. ( Abstract )
London J.W., Morton D.E., Marinucci D., Catalano R., and Comis R.L.: Telemedicine case study: Using desktop personal video conferencing for consultations between physicians in a community cancer network, Toward An Electronic Patient Record '97, Nashville, 1997.
London, J. W., Morton D.E., Marinucci D., Catalano R., and Comis R.L.: The Utilization of the World Wide Web and Telemedicine to Increase Participation in Cancer Clinical Research, Computers in Healthcare Education Symposium, Philadelphia, 1997.
London J.W.: Telemedicine case study: Using desktop personal video conferencing for consultations between physicians in a community cancer network, Disease Management Congress, Phoenix, 1997.
London, J. W., Morton D.E., Marinucci D., Catalano R., and Comis R.L.: The Implementation of Telemedicine Within a Community Cancer Network, American Medical Informatics Association Spring Congress, Kansas City, 1996.
London J. W., Morton D.E., Marinucci D., Catalano R., and Comis, R.L., Strategies for PC/ISDN-based Telemedicine Consultations. In Proceedings of the 10th International Symposium on Computer Assisted Radiology, Paris 1996, H.U. Lemke, M.W. Vannier, K. Inamura, and A.G. Farman (eds.), pp 585-590.
London J. W., Morton D.E., Comis, R.L., Low-Cost Image Consultation Workstations Utilizing ISDN and Personal Computers. In Proceedings of the 9th International Symposium on Computer Assisted Radiology, Berlin 1995, H.U. Lemke, C.C. Jaffe, and M.W. Vannier (eds.), pp 759-764.
London, J. W., Morton D.E., Marinucci D., Catalano R., and Comis R.L.: Cost Effective Internet Access and Video Conferencing for a Community Cancer Network. In Proceedings of the Nineteenth Annual Symposium on Computer Applications in Medical Care, New Orleans, 1995, R. M. Gardner (ed.), pp 781-784.
Engelmann U, London JW, Meinzer HP, Schroter A, Morton DE, Schaefer M, Degoulet P. Integration of a European image processing component with an American HIS: the advantage of open standards. Comput Methods Programs Biomed 1995 Sep-Oct;48(1-2):109-14.. ( Abstract )
London JW, Morton DE, Marinucci D, Catalano R, Comis RL. Cost effective Internet access and video conferencing for a community cancer network. Proc Annu Symp Comput Appl Med Care 1995;:781-4.. ( Abstract )
London JW, Engelmann U, Morton DE, Meinzer HP, Degoulet P. Integration of HIS components through open standards: an American HIS and a European Image Processing System. Proc Annu Symp Comput Appl Med Care 1993;:149-53.. ( Abstract )
London JW, Morton DE. A network scanner image management station. J Digit Imaging 1992 Feb;5(1):7-13.. ( Abstract )
London JW, Morton DE, Polekoff D, Reber J. The use of X-terminals as clinical workstations. J Med Syst 1991 Feb;15(1):3-9. ( Abstract )
London JW. Effective computing with clusters. Comput Healthc 1988 Aug;9(8):16-7.. ( Abstract )
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