Hallgeir Rui, M.D., Ph.D.


Professor
Cancer Biology

Telephone
215-503-9259

Office Address
332 BLSB
233 S. 10th St.

Email Address
hallgeir.rui@jefferson.edu

 

Qualifications
MD, University of Oslo, Norway - 1980-1987
PhD, Pathology, University of Oslo, Norway - 1983-1988

Expertise & Research Interests
Dr. Rui has made a series of contributions to increased understanding of the molecular mechanisms of signal transduction by receptors for prolactin and related cytokines and hormones. Dr. Rui was the first to isolate a prolactin  receptor-associated tyrosine kinase, and to identify this molecule as Janus kinase-2. Dr. Rui's laboratory has maintained a focus on prolactin receptor function with a primary goal of understanding the role of  downstream Jak-Stat pathways and their aberrations in breast cancer.

Activation of Stat5 is a strong favorable prognostic marker in breast cancer and an invasion-suppressive role of Stat5 in human breast cancer may represent a biological mechanism. Loss of Stat5 is further associated with increased risk of antiestrogen resistance. Dr. Rui and his team have also invented and applied a new technology to generate  high density tumor tissue arrays for high-through-put molecular  profiling. Dr. Rui is the PI of a $6.7 million, 5 year Komen Promise  Grant to a consortium of multidisciplinary investigators to classify malignant breast tumors based on expression of druggable target proteins for improved personalized cancer care. The consortium project also involves a novel Bayesian adaptive biomarker-centered Phase II clinical trial of a Parp-inhibitor in the neoadjuvant setting for triple-negative breast cancer.

Cancer Biology Profile            Google Scholar   


Keywords: cancer; breast cancer; hormone; endocrinology; prolactin; growth hormone; estrogen; glucocorticoid; steroid hormones; Jak2; Stat5; Stat5a; Stat5b; immunohistochemistry; pathology; biomarker; early detection; microarray; tissue microarray; mouse modeling; EGFR; Her2; ErbB2; prolactin receptor;
 

PubMed Link For Rui H


 

Web page revised: August 14, 2014.
URL: http://www.kcc.tju.edu/kcc/kccnew/staff/staffdefault.php


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